#Cytoscape pathway software#

#Cytoscape pathway software#

Cytoscape is an open source bioinformatics software platform for visualizing molecular interaction networks and biological pathways and integrating these networks with annotations, gene expression profiles and other state data. Together, these results provide a resource to elucidate gene regulatory mechanisms underlying the progressive development of BAT during early life. Cytoscape: Analyzing and Visualizing Network Data. In addition, these results indicate a sequential order of transcriptional events affecting cellular pathways, which could potentially explain the variation in the amount, or activity, of BAT in adulthood. Using weighted gene coexpression network analyses, we found precise anthropometric-specific correlations with changes in gene expression and the decline of thermogenic capacity within EAT. bioCycPlugin: Cytoscape plugin for loading pathways from Pathway Tools web services. Our results also indicated that the pattern of gene expression represents a distinct developmental stage, even after the rebound in abundance of thermogenic genes in later childhood. Surprisingly, these analyses revealed that the transition to infancy is a critical stage for changes in the morphology of EAT and is reflected in unique gene expression patterns of a substantial proportion of thermogenic gene transcripts (~10%). Cytoscape is domain-independent and therefore is a powerful tool for complex network analysis in general. Here, we obtained samples of epicardial adipose tissue (EAT) from neonates, infants, and children in order to evaluate changes in their transcriptional landscape by applying a systems biology approach. Studies in rodents and newborn humans demonstrate the influence of brown adipose tissue (BAT) in temperature control and energy balance and a critical role in the regulation of body weight. Using the pathway visualization and analysis features, you can load pathways in the Reactome database into Cytoscape, visualize Reactome.